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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EGFR All Species: 8.48
Human Site: S1162 Identified Species: 16.97
UniProt: P00533 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P00533 NP_005219.2 1210 134277 S1162 A H W A Q K G S H Q I S L D N
Chimpanzee Pan troglodytes XP_519102 1210 134401 S1162 A H W A Q K G S H Q I S L D N
Rhesus Macaque Macaca mulatta XP_001107305 1120 124266 A1076 Y S S D P T G A L T E D S I D
Dog Lupus familis XP_533073 1595 175523 H1548 L W T Q E A N H Q I S L D N P
Cat Felis silvestris
Mouse Mus musculus Q01279 1210 134835 S1162 A L W I Q K G S H Q M S L D N
Rat Rattus norvegicus Q62956 1308 146940 E1168 E Y L N P V E E N P F V S R R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507339 1187 132966 N1137 S Y W D Q K A N H Q I N L D N
Chicken Gallus gallus P13387 703 77409 V659 T P S I A A G V V G G L L C L
Frog Xenopus laevis Q91694 985 109711 E940 A A G Y T S L E A V V H V N Q
Zebra Danio Brachydanio rerio NP_919405 1191 132465 H1143 V E Y L N T S H T Q L L S T K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P04412 1426 159700 M1381 Q T I G I P V M G G P G T M E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P24348 1323 150493 L1243 A Q E D N S Y L I P K T K E V
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 90.3 69.5 N.A. 90.5 49.4 N.A. 82.1 42.4 21.8 62.4 N.A. 35.2 N.A. 27.7 N.A.
Protein Similarity: 100 99.6 91.4 72.6 N.A. 95 64.6 N.A. 88.4 48.2 37.4 74 N.A. 51.1 N.A. 46.7 N.A.
P-Site Identity: 100 100 6.6 0 N.A. 80 0 N.A. 60 13.3 6.6 6.6 N.A. 0 N.A. 6.6 N.A.
P-Site Similarity: 100 100 20 13.3 N.A. 86.6 13.3 N.A. 86.6 13.3 26.6 20 N.A. 0 N.A. 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 42 9 0 17 9 17 9 9 9 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % C
% Asp: 0 0 0 25 0 0 0 0 0 0 0 9 9 34 9 % D
% Glu: 9 9 9 0 9 0 9 17 0 0 9 0 0 9 9 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % F
% Gly: 0 0 9 9 0 0 42 0 9 17 9 9 0 0 0 % G
% His: 0 17 0 0 0 0 0 17 34 0 0 9 0 0 0 % H
% Ile: 0 0 9 17 9 0 0 0 9 9 25 0 0 9 0 % I
% Lys: 0 0 0 0 0 34 0 0 0 0 9 0 9 0 9 % K
% Leu: 9 9 9 9 0 0 9 9 9 0 9 25 42 0 9 % L
% Met: 0 0 0 0 0 0 0 9 0 0 9 0 0 9 0 % M
% Asn: 0 0 0 9 17 0 9 9 9 0 0 9 0 17 34 % N
% Pro: 0 9 0 0 17 9 0 0 0 17 9 0 0 0 9 % P
% Gln: 9 9 0 9 34 0 0 0 9 42 0 0 0 0 9 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 9 % R
% Ser: 9 9 17 0 0 17 9 25 0 0 9 25 25 0 0 % S
% Thr: 9 9 9 0 9 17 0 0 9 9 0 9 9 9 0 % T
% Val: 9 0 0 0 0 9 9 9 9 9 9 9 9 0 9 % V
% Trp: 0 9 34 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 17 9 9 0 0 9 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _